Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 113-115.doi: 10.3969/j.issn.1673-8225.2011. 01.025

Previous Articles     Next Articles

Application of embryonic stem cells to reproductive medicine

Liu Li-qing1, Li Juan2, Zhou Sheng-nian3    

  1. 1Shandong University of Traditional Chinese Medicine, Jinan  250355, Shandong Province, China
    2Master postgraduate in 2008, Shandong University of Traditional Chinese Medicine, Jinan  250355, Shandong Province, China
    3Qilu Hospital, Shandong University, Jinan  250012, Shandong Province, China
  • Received:2010-06-12 Revised:2010-09-25 Online:2011-01-01 Published:2011-01-01
  • Contact: Zhou Sheng-nian, Doctoral supervisor, Professor, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China zhoushengnian126@126.com
  • About author:Liu Li-qing, Professor, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China liuliqing123@tom.com
  • Supported by:

    the Science and Technology Foundation of Shandong Province, No. 2007GG10002017; the Natural Foundation of Shandong Province, No. Y 2008C63; the Traditional Chinese Medicine Research Program of Shandong Province, No. 2009-002

PDF

512

Abstract:

BACKGROUND: It has been reported that embryonic stem cells can differentiate into primordial germ cells in vitro culture and to further generate gametes then develop into blastocysts after fertilization, and produce live filial generation.
OBJECTIVE: To expound the research progress of embryonic stem cells in reproductive medicine in recent years.
METHODS: Tongfang database system was used to search for research articles published from 2000 to 2009 on germ cells and Chinese medicine related to the key words “germ cells, medicine”, and the language was limited to Chinese; the same searching PubMed database articles published from 1998 to 2009 with the key words of “embryonic stem cells, stem cells, germ cells, oocyte, sperm, differentiation”, and the language was limited to English.
RESULTS AND CONCLUSION: Embryonic stem cells in vitro differentiation affected by internal and external factors, can be induced to differentiate into sperm and oocytes, is an ideal model on the study of early embryonic development in mammals. At present, it is feasible to in vitro culture primordial germ cells and gamete, but the characteristics and function of in vitro cultured germ cells remain unclear and it is necessary to further identify its safety and efficacy in clinic.

CLC Number: